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MaxPower wrote:Team,
Where has the BEST vaccine?
Looking for a top notch nice fancy facility with NO waiting.
Who do i have to pay and what kinda costing we looking at?
shake d livin wake d dead wrote:MaxPower wrote:Team,
Where has the BEST vaccine?
Looking for a top notch nice fancy facility with NO waiting.
Who do i have to pay and what kinda costing we looking at?
Keep looking
New data from CDC on effectiveness of Pfizer and Moderna COVID-19 vaccines
Sally Robertson, B.Sc.
By Sally Robertson, B.Sc.Jun 6 2021
Researchers in the United States have conducted a study demonstrating the real-world effectiveness of the Pfizer-BioNTech and Moderna coronavirus disease 2019 (COVID-19) vaccines at preventing infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Importantly, Mark Thompson from the CDC COVID-19 Response Team and colleagues also showed that the vaccines were highly effective at reducing viral load, febrile symptoms, and the duration of illness among individuals who developed breakthrough infections despite having been vaccinated.
The large prospective study of almost 4,000 people found that full vaccination (with two doses) was 91% effective at preventing SARS-CoV-2 infection, while partial vaccination (with one dose) was 81% effective.
Among those who became infected, partially or fully vaccinated individuals had a lower level of viral RNA, a lower risk of developing febrile symptoms and a reduced duration of illness compared with unvaccinated individuals.
The researchers say that if further data confirm that these vaccines reduce the viral load and, in turn, blunt the infectivity of SARS-CoV-2, this would suggest that the vaccines are not only highly effective at preventing infection, but could also reduce the impact of breakthrough infections.
This has significant implications for essential and frontline workers, given their potential to spread the virus through frequent close contact with patients, co-workers, and the public, says Thompson and colleagues.
A pre-print version of the research paper is available on the medRxiv* server, while the article undergoes peer review.
The potentially important secondary benefits of mRNA-based COVID-19 vaccines
The messenger RNA- (mRNA) based vaccines developed by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) have been shown to be highly effective in preventing symptomatic COVID-19 in Phase III clinical trials.
Thompson and colleagues also recently reported interim estimates of effectiveness that showed similar benefits following the administration of mRNA-based vaccines in real-world conditions.
However, “less is known about the potentially important secondary benefits of mRNA COVID-19 vaccines, including reductions in severity of disease, viral RNA load, and duration of viral RNA detection,” says the team.
What did the researchers do?
Now, Thompson and colleagues have analyzed prospective cohorts of 3,975 healthcare personnel, first responders, and other essential and frontline workers across eight locations in the United States who completed weekly SARS-CoV-2 testing between December 14th, 2020, and April 10th, 2021.
The researchers estimated the efficacy of partial and full vaccination in preventing SARS-CoV-2 infection and compared the viral RNA load of vaccinees who had breakthrough infection with that of unvaccinated infected participants. The team also compared the frequency of febrile symptoms and the duration of COVID-19 between the vaccinated and unvaccinated groups.
Participants self-collected a mid-turbinate nasal swab on a weekly basis, irrespective of whether they had COVID-19-like symptoms. Individuals who developed COVID-19 like illness also collected a further nasal swab and saliva specimen at symptom onset.
Samples were tested for SARS-CoV-2 infection using qualitative and quantitative reverse-transcription–polymerase-chain-reaction (RT-PCR). Vaccine efficacy was estimated for full vaccination (14 days or more following a second dose) and partial vaccination (14 days or more following one dose or up to 13 days following a second dose).
Vaccinated individuals had received either Pfizer-BioNTech’s BNT162b2 vaccine or Moderna’s mRNA-1273 vaccine and efficacy was calculated following adjustment for location, occupation and local virus circulation.
What did the study find?
The number of participants who had RT-PCR-confirmed SARS-CoV-2 infection was 204 (5.1%), 16 of whom were partially or fully vaccinated and 156 of whom were unvaccinated.
Vaccination status was indeterminate (less than 14 days since the first dose) for 32 individuals who were therefore excluded from the study.
The estimated effectiveness of vaccination at protecting against SARS-CoV-2 infection was 91% for full vaccination and 81% for partial vaccination.
Of the participants who became infected, the mean viral RNA load (Log10 copies/mL) detected was 2.3 among partially or fully vaccinated participants, compared with 3.8 among unvaccinated participants.
An adjusted analysis represented a 40.2% lower viral RNA load following at least partial vaccination.
Only 25% of at least partially vaccinated individuals reported febrile COVID-19–like illness, compared with 63.1% of unvaccinated individuals.
This represented a 58% reduction in the relative risk of febrile COVID19–like symptoms after at least partial vaccination.
Vaccinated participants also reported 6.4 fewer days of feeling ill than unvaccinated participants.
What are the study implications?
The researchers say the estimates of vaccine effectiveness reported here in the real-world setting are consistent with findings from clinical trials.
They also say the combination of virologic and clinical effects is consistent with previous reports of a lower quantity and duration of viral RNA detection and milder COVID-19 following mRNA-based vaccination.
“If further data confirm that mRNA vaccination reduces the number of viral RNA particles and the duration of detection and this in turn blunts the infectivity of SARS-CoV-2, then mRNA vaccines are not only highly effective in preventing SARS-CoV-2 infection, but they may also mitigate the impact of breakthrough infections,” says the team.
“This is especially important to essential and frontline workers given their potential to transmit the virus through frequent close contacts with patients, co-workers, and the public,” concludes Thompson and colleagues.
*Important Notice
medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Journal reference:
Thompson M, et al. Prevention and Attenuation of COVID-19 by BNT162b2 and mRNA-1273 Vaccines. medRxiv, 2021. doi: https://doi.org/10.1101/2021.06.01.21257987
adnj wrote:Already posted earlier in this threadSuperiorMan wrote:Canada says COVID-19 vaccine doses are 'interchangeable,' encouraging mix-and-match vaccines while the CDC still stands firmly against it
https://www.businessinsider.com/coronav ... nst-2021-6
Canada has released guidance saying that mRNA vaccines from Pfizer and Moderna are interchangeable, and that an mRNA vaccine can safely be administered after a first dose of AstraZeneca vaccine.
The move from Canada's Public Health Agency comes in contrast to the guidance from the US Centers for Disease Control and Prevention, which recommends that vaccine mixing be avoided except in "exceptional situations."
Here are the acceptable combinations, according to Canada's new guidance:
Preferred: Pfizer (first shot) and Pfizer (second shot); or Moderna (first shot) and Moderna (second shot).
Acceptable: Pfizer and Moderna; or Moderna and Pfizer.
Equally acceptable: AstraZeneca and AstraZeneca; AstraZeneca and Moderna; or AstraZeneca and Pfizer.
In other words, according to Canada's new guidance, people who received a dose of mRNA vaccine should be given the same vaccine if it is readily available, but an alternative brand of mRNA vaccine can be offered. Those who had an AstraZeneca vaccine for the first dose can also be the offered the same or an mRNA vaccine interchangeably, the guidance said.
The Canadian advice shows a clear preference for mRNA vaccines, namely those from Pfizer and Moderna. The AstraZeneca does not use mRNA technology.
The Canadian health agency also noted that due to the risk of people developing rare blood clots from the AstraZeneca vaccine, offering alternative vaccines was "ethically justifiable."
Canada currently uses vaccines from Pfizer, Moderna, and AstraZeneca, as well as Johnson & Johnson, which uses a single shot.
Mounting evidence that vaccine-mixing is safe and effective
Canada's updated guidance was based on rising evidence that mixing vaccines is safe and effective, including recent results from Spain, the UK, and Germany, the country's National Advisory Committee on Immunization (NACI) said in a press release.
Mixing brands of vaccines against the same illness is "not a new concept," and has been safely used to complete vaccination against the flu, Hepatitis A, and other diseases, NACI said.
Several countries, including France and Germany, have already recommended using alternative vaccines to the AstraZeneca shot in younger populations for their second dose — without waiting for scientific bodies to prove that it is safe — after unusual blood clots were seen in very rare cases after receiving the vaccine.
By contrast, the CDC has said that if vaccine mixing occurs, it should be considered an "administrative error" that needs to be reported to the national safety monitoring system.
http://www.trinituner.com/v4/forums/vie ... #p10169601
http://www.trinituner.com/v4/forums/vie ... #p10169607
shake d livin wake d dead wrote:This is gonna be the trend from now on...starting with private sector
Parasram talking cdc crap?SuperiorMan wrote:adnj wrote:Already posted earlier in this threadSuperiorMan wrote:Canada says COVID-19 vaccine doses are 'interchangeable,' encouraging mix-and-match vaccines while the CDC still stands firmly against it
https://www.businessinsider.com/coronav ... nst-2021-6
Canada has released guidance saying that mRNA vaccines from Pfizer and Moderna are interchangeable, and that an mRNA vaccine can safely be administered after a first dose of AstraZeneca vaccine.
The move from Canada's Public Health Agency comes in contrast to the guidance from the US Centers for Disease Control and Prevention, which recommends that vaccine mixing be avoided except in "exceptional situations."
Here are the acceptable combinations, according to Canada's new guidance:
Preferred: Pfizer (first shot) and Pfizer (second shot); or Moderna (first shot) and Moderna (second shot).
Acceptable: Pfizer and Moderna; or Moderna and Pfizer.
Equally acceptable: AstraZeneca and AstraZeneca; AstraZeneca and Moderna; or AstraZeneca and Pfizer.
In other words, according to Canada's new guidance, people who received a dose of mRNA vaccine should be given the same vaccine if it is readily available, but an alternative brand of mRNA vaccine can be offered. Those who had an AstraZeneca vaccine for the first dose can also be the offered the same or an mRNA vaccine interchangeably, the guidance said.
The Canadian advice shows a clear preference for mRNA vaccines, namely those from Pfizer and Moderna. The AstraZeneca does not use mRNA technology.
The Canadian health agency also noted that due to the risk of people developing rare blood clots from the AstraZeneca vaccine, offering alternative vaccines was "ethically justifiable."
Canada currently uses vaccines from Pfizer, Moderna, and AstraZeneca, as well as Johnson & Johnson, which uses a single shot.
Mounting evidence that vaccine-mixing is safe and effective
Canada's updated guidance was based on rising evidence that mixing vaccines is safe and effective, including recent results from Spain, the UK, and Germany, the country's National Advisory Committee on Immunization (NACI) said in a press release.
Mixing brands of vaccines against the same illness is "not a new concept," and has been safely used to complete vaccination against the flu, Hepatitis A, and other diseases, NACI said.
Several countries, including France and Germany, have already recommended using alternative vaccines to the AstraZeneca shot in younger populations for their second dose — without waiting for scientific bodies to prove that it is safe — after unusual blood clots were seen in very rare cases after receiving the vaccine.
By contrast, the CDC has said that if vaccine mixing occurs, it should be considered an "administrative error" that needs to be reported to the national safety monitoring system.
http://www.trinituner.com/v4/forums/vie ... #p10169601
http://www.trinituner.com/v4/forums/vie ... #p10169607
The major point was that the CDC was against it. Nobody really touched on that. The first link you had didn't talk about it and the second link was just the headline.
If you feel the need to repost an entire article two days after it was already posted in the same thread just to start some more §hit, have at it.SuperiorMan wrote:adnj wrote:Already posted earlier in this threadSuperiorMan wrote:Canada says COVID-19 vaccine doses are 'interchangeable,' encouraging mix-and-match vaccines while the CDC still stands firmly against it
https://www.businessinsider.com/coronav ... nst-2021-6
Canada has released guidance saying that mRNA vaccines from Pfizer and Moderna are interchangeable, and that an mRNA vaccine can safely be administered after a first dose of AstraZeneca vaccine.
The move from Canada's Public Health Agency comes in contrast to the guidance from the US Centers for Disease Control and Prevention, which recommends that vaccine mixing be avoided except in "exceptional situations."
Here are the acceptable combinations, according to Canada's new guidance:
Preferred: Pfizer (first shot) and Pfizer (second shot); or Moderna (first shot) and Moderna (second shot).
Acceptable: Pfizer and Moderna; or Moderna and Pfizer.
Equally acceptable: AstraZeneca and AstraZeneca; AstraZeneca and Moderna; or AstraZeneca and Pfizer.
In other words, according to Canada's new guidance, people who received a dose of mRNA vaccine should be given the same vaccine if it is readily available, but an alternative brand of mRNA vaccine can be offered. Those who had an AstraZeneca vaccine for the first dose can also be the offered the same or an mRNA vaccine interchangeably, the guidance said.
The Canadian advice shows a clear preference for mRNA vaccines, namely those from Pfizer and Moderna. The AstraZeneca does not use mRNA technology.
The Canadian health agency also noted that due to the risk of people developing rare blood clots from the AstraZeneca vaccine, offering alternative vaccines was "ethically justifiable."
Canada currently uses vaccines from Pfizer, Moderna, and AstraZeneca, as well as Johnson & Johnson, which uses a single shot.
Mounting evidence that vaccine-mixing is safe and effective
Canada's updated guidance was based on rising evidence that mixing vaccines is safe and effective, including recent results from Spain, the UK, and Germany, the country's National Advisory Committee on Immunization (NACI) said in a press release.
Mixing brands of vaccines against the same illness is "not a new concept," and has been safely used to complete vaccination against the flu, Hepatitis A, and other diseases, NACI said.
Several countries, including France and Germany, have already recommended using alternative vaccines to the AstraZeneca shot in younger populations for their second dose — without waiting for scientific bodies to prove that it is safe — after unusual blood clots were seen in very rare cases after receiving the vaccine.
By contrast, the CDC has said that if vaccine mixing occurs, it should be considered an "administrative error" that needs to be reported to the national safety monitoring system.
http://www.trinituner.com/v4/forums/vie ... #p10169601
http://www.trinituner.com/v4/forums/vie ... #p10169607
The major point was that the CDC was against it. Nobody really touched on that. The first link you had didn't talk about it and the second link was just the headline.
sMASH wrote:Parasram talking cdc crap?SuperiorMan wrote:adnj wrote:Already posted earlier in this threadSuperiorMan wrote:Canada says COVID-19 vaccine doses are 'interchangeable,' encouraging mix-and-match vaccines while the CDC still stands firmly against it
https://www.businessinsider.com/coronav ... nst-2021-6
Canada has released guidance saying that mRNA vaccines from Pfizer and Moderna are interchangeable, and that an mRNA vaccine can safely be administered after a first dose of AstraZeneca vaccine.
The move from Canada's Public Health Agency comes in contrast to the guidance from the US Centers for Disease Control and Prevention, which recommends that vaccine mixing be avoided except in "exceptional situations."
Here are the acceptable combinations, according to Canada's new guidance:
Preferred: Pfizer (first shot) and Pfizer (second shot); or Moderna (first shot) and Moderna (second shot).
Acceptable: Pfizer and Moderna; or Moderna and Pfizer.
Equally acceptable: AstraZeneca and AstraZeneca; AstraZeneca and Moderna; or AstraZeneca and Pfizer.
In other words, according to Canada's new guidance, people who received a dose of mRNA vaccine should be given the same vaccine if it is readily available, but an alternative brand of mRNA vaccine can be offered. Those who had an AstraZeneca vaccine for the first dose can also be the offered the same or an mRNA vaccine interchangeably, the guidance said.
The Canadian advice shows a clear preference for mRNA vaccines, namely those from Pfizer and Moderna. The AstraZeneca does not use mRNA technology.
The Canadian health agency also noted that due to the risk of people developing rare blood clots from the AstraZeneca vaccine, offering alternative vaccines was "ethically justifiable."
Canada currently uses vaccines from Pfizer, Moderna, and AstraZeneca, as well as Johnson & Johnson, which uses a single shot.
Mounting evidence that vaccine-mixing is safe and effective
Canada's updated guidance was based on rising evidence that mixing vaccines is safe and effective, including recent results from Spain, the UK, and Germany, the country's National Advisory Committee on Immunization (NACI) said in a press release.
Mixing brands of vaccines against the same illness is "not a new concept," and has been safely used to complete vaccination against the flu, Hepatitis A, and other diseases, NACI said.
Several countries, including France and Germany, have already recommended using alternative vaccines to the AstraZeneca shot in younger populations for their second dose — without waiting for scientific bodies to prove that it is safe — after unusual blood clots were seen in very rare cases after receiving the vaccine.
By contrast, the CDC has said that if vaccine mixing occurs, it should be considered an "administrative error" that needs to be reported to the national safety monitoring system.
http://www.trinituner.com/v4/forums/vie ... #p10169601
http://www.trinituner.com/v4/forums/vie ... #p10169607
The major point was that the CDC was against it. Nobody really touched on that. The first link you had didn't talk about it and the second link was just the headline.
Video clip of hims saying they know about mixing vaccines. And he watching.
Mix the bleddy vaccines!
All they all are doing, is triggering off 6he responses in more or less the same way.
Unless they tailor some specifically to the different variants, it's not going to be much if an issue except for potency.
Unless I can identify and state what are the negative effects of the various combinations, that mixing hesitancy is an irrational fear.
U already taking emergency approved substances, might as well go full.
sMASH wrote:Parasram talking cdc crap?SuperiorMan wrote:adnj wrote:Already posted earlier in this threadSuperiorMan wrote:Canada says COVID-19 vaccine doses are 'interchangeable,' encouraging mix-and-match vaccines while the CDC still stands firmly against it
https://www.businessinsider.com/coronav ... nst-2021-6
Canada has released guidance saying that mRNA vaccines from Pfizer and Moderna are interchangeable, and that an mRNA vaccine can safely be administered after a first dose of AstraZeneca vaccine.
The move from Canada's Public Health Agency comes in contrast to the guidance from the US Centers for Disease Control and Prevention, which recommends that vaccine mixing be avoided except in "exceptional situations."
Here are the acceptable combinations, according to Canada's new guidance:
Preferred: Pfizer (first shot) and Pfizer (second shot); or Moderna (first shot) and Moderna (second shot).
Acceptable: Pfizer and Moderna; or Moderna and Pfizer.
Equally acceptable: AstraZeneca and AstraZeneca; AstraZeneca and Moderna; or AstraZeneca and Pfizer.
In other words, according to Canada's new guidance, people who received a dose of mRNA vaccine should be given the same vaccine if it is readily available, but an alternative brand of mRNA vaccine can be offered. Those who had an AstraZeneca vaccine for the first dose can also be the offered the same or an mRNA vaccine interchangeably, the guidance said.
The Canadian advice shows a clear preference for mRNA vaccines, namely those from Pfizer and Moderna. The AstraZeneca does not use mRNA technology.
The Canadian health agency also noted that due to the risk of people developing rare blood clots from the AstraZeneca vaccine, offering alternative vaccines was "ethically justifiable."
Canada currently uses vaccines from Pfizer, Moderna, and AstraZeneca, as well as Johnson & Johnson, which uses a single shot.
Mounting evidence that vaccine-mixing is safe and effective
Canada's updated guidance was based on rising evidence that mixing vaccines is safe and effective, including recent results from Spain, the UK, and Germany, the country's National Advisory Committee on Immunization (NACI) said in a press release.
Mixing brands of vaccines against the same illness is "not a new concept," and has been safely used to complete vaccination against the flu, Hepatitis A, and other diseases, NACI said.
Several countries, including France and Germany, have already recommended using alternative vaccines to the AstraZeneca shot in younger populations for their second dose — without waiting for scientific bodies to prove that it is safe — after unusual blood clots were seen in very rare cases after receiving the vaccine.
By contrast, the CDC has said that if vaccine mixing occurs, it should be considered an "administrative error" that needs to be reported to the national safety monitoring system.
http://www.trinituner.com/v4/forums/vie ... #p10169601
http://www.trinituner.com/v4/forums/vie ... #p10169607
The major point was that the CDC was against it. Nobody really touched on that. The first link you had didn't talk about it and the second link was just the headline.
Video clip of hims saying they know about mixing vaccines. And he watching.
Mix the bleddy vaccines!
All they all are doing, is triggering off 6he responses in more or less the same way.
Unless they tailor some specifically to the different variants, it's not going to be much if an issue except for potency.
Unless I can identify and state what are the negative effects of the various combinations, that mixing hesitancy is an irrational fear.
U already taking emergency approved substances, might as well go full.
How did you get an appointment?Dizzy28 wrote:Vaccine day for me - AZ.
Will let you all know how it goes.
There's a mass vaccination day for haters coming up. That's when they'll take care of you.zoom rader wrote:How did you get an appointment?Dizzy28 wrote:Vaccine day for me - AZ.
Will let you all know how it goes.
There seems to be no one protocol
Sorry boss ,adnj wrote:There's a mass vaccination day for haters coming up. That's when they'll take care of you.zoom rader wrote:How did you get an appointment?Dizzy28 wrote:Vaccine day for me - AZ.
Will let you all know how it goes.
There seems to be no one protocol
zoom rader wrote:How did you get an appointment?Dizzy28 wrote:Vaccine day for me - AZ.
Will let you all know how it goes.
There seems to be no one protocol
And you were able to get an exemption to return from this red govt? Lucky......or......hmmmm....zoom rader wrote:Sorry boss ,adnj wrote:There's a mass vaccination day for haters coming up. That's when they'll take care of you.zoom rader wrote:How did you get an appointment?Dizzy28 wrote:Vaccine day for me - AZ.
Will let you all know how it goes.
There seems to be no one protocol
I got mine abroad in the Cayman Islands, I was two steps ahead of Red government and their failure
It was haters' training camp - completely above board.wing wrote:And you were able to get an exemption to return from this red govt? Lucky......or......hmmmm....zoom rader wrote:Sorry boss ,adnj wrote:There's a mass vaccination day for haters coming up. That's when they'll take care of you.zoom rader wrote:How did you get an appointment?Dizzy28 wrote:Vaccine day for me - AZ.
Will let you all know how it goes.
There seems to be no one protocol
I got mine abroad in the Cayman Islands, I was two steps ahead of Red government and their failure
carluva wrote:^^^^ Great!
Can you keep us posted on mum, bro and sis-in-law with the health issues?
sMASH wrote:are ALLL vaccines 100% effective in preventing severe cases, hospitalizations and deaths?
Dohplaydat wrote:sMASH wrote:are ALLL vaccines 100% effective in preventing severe cases, hospitalizations and deaths?
Yea for the most part, Sinopharm is perhaps a little less effective in this compared to the others, but it's still quite good at this.
Strugglerzinc wrote:carluva wrote:^^^^ Great!
Can you keep us posted on mum, bro and sis-in-law with the health issues?
One had no reaction, one had slight fever and the third, my bro under 40 and hypertensive had full on fever, chills and body pains. All fine now.
Mmoney607 wrote:Dohplaydat wrote:sMASH wrote:are ALLL vaccines 100% effective in preventing severe cases, hospitalizations and deaths?
Yea for the most part, Sinopharm is perhaps a little less effective in this compared to the others, but it's still quite good at this.
I think so to, I have no reason to doubt that it prevents severe cases.
You have doubts smash?
I heard fuad khan this morning saying that sinopharm is the best vaccine and he took AZ as his 1st shot but now he wants sinopharm as the second.
teems1 wrote:Mmoney607 wrote:Dohplaydat wrote:sMASH wrote:are ALLL vaccines 100% effective in preventing severe cases, hospitalizations and deaths?
Yea for the most part, Sinopharm is perhaps a little less effective in this compared to the others, but it's still quite good at this.
I think so to, I have no reason to doubt that it prevents severe cases.
You have doubts smash?
I heard fuad khan this morning saying that sinopharm is the best vaccine and he took AZ as his 1st shot but now he wants sinopharm as the second.
Of the "whole virus" types of vaccines, Sinopharm is best, but the others in this category are the Sinovac and Bharat from India.
I think the mRNA vaccines are usually preferred, as they can be used on persons with weaker immune systems.
mRNA vaccine (Pfizer/Moderna) Injects messenger RNA (recipe to make a protein) into your body. Your body creates the protein, Antibodies kill the spike protein so your body is now safe.
Protein subunit vaccine (Novovax). Instead of injecting the recipe for the protein, the protein itself is injected. Antibodies kill it.
Adenovirus vaccine (AZ/J&J) Injects a modified version of a chimpanzee virus into the body. This chimpanzee virus cannot replicate, but the body sees it as COVID so it builds the antibodies for it.
Whole virus vaccine (Sinopharm/Sinovac/Bharat). Injects a weak or inactivated version of the virus into your body. Your body detects it and fights it off. This is the most traditional version of vaccines that we're most accustomed to.
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