Moderator: 3ne2nr Mods
Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study
...
Findings
Analyses were done for 11 123 hospital or emergency department admissions. In adjusted analyses, effectiveness of two doses of the BNT162b2 vaccine against the omicron variant was 41% (95% CI 21–55) against hospital admission and 31% (16–43) against emergency department admission at 9 months or longer after the second dose.
...
paid_influencer wrote:this was posted, right?
In the LancetDurability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study
...
Findings
Analyses were done for 11 123 hospital or emergency department admissions. In adjusted analyses, effectiveness of two doses of the BNT162b2 vaccine against the omicron variant was 41% (95% CI 21–55) against hospital admission and 31% (16–43) against emergency department admission at 9 months or longer after the second dose.
...
Through normsl regulatory process, or still under emergency use?redmanjp wrote:paid_influencer wrote:this was posted, right?
In the LancetDurability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study
...
Findings
Analyses were done for 11 123 hospital or emergency department admissions. In adjusted analyses, effectiveness of two doses of the BNT162b2 vaccine against the omicron variant was 41% (95% CI 21–55) against hospital admission and 31% (16–43) against emergency department admission at 9 months or longer after the second dose.
...
a 3rd dose is better. but what we need going forward is omicron specific vaccines which moderna is making
It depends.redmanjp wrote:but even if u are reinfected, previous infection still protects against severity, not so?
Interesting write-up of a biorxiv preprint re Omicron sublineage immune evasion. Three key points:
-the BA2.12/BA4/BA5 variants show higher immune evasion to specifically BA1+vaccinated plasma
-consequently BA1-targeting boosters could actually be a poor choice for getting broader protection
-Bebtelovimab is still working against all extant variantsResults
The study results showed that the Omicron BA.2 sublineages, such as BA.2.13 and BA.2.12.1, had higher ACE2-binding affinities than BA.1, but BA.5/BA.4 has the poorest receptor-binding ability due to R493Q and F486V reversion using structural comparisons. BA.5/BA.4 and BA.2.12.1 relative to BA.2 showed higher neutralization evasion from the plasma of three-dose vaccinees and, most notably, from vaccinated BA.1 convalescents.
..
Nevertheless, due to the high sensitivity to E484, N440, N501, and K417 mutations, BA.1 infection could also generate new clones of BA.1-specific antibodies that could neutralize BA.1 yet not the SARS-CoV-2 WT strain. Interestingly, because of F486V and D405N, these NAbs were mostly evaded by BA.2 subvariants and BA.5/BA.4, which have narrow neutralization breadths. In terms of therapeutic NAbs, CoV2-2130 (Cilgavimab) and LY-CoV1404 (Bebtelovimab) could still neutralize BA.5/BA.4 and BA.2.12.1, albeit the R408S, S371F, and D405N mutations harbored by the BA.5/BA.2/BA.4 sublineages would render most expansive sarbecovirus NAbs useless.
These data imply that various recent Omicron sublineages could develop mutations to avoid humoral immunity induced by the Omicron BA.1 subvariant infection. Omicron's continued advancement presents significant hurdles to SARS-CoV-2 herd immunity, suggesting that BA.1-derived COVID-19 vaccine boosters might not be the best option for obtaining broad protection.
Letting this virus spread widely through the global population is accelerating viral evasion and the degradation of vaccine+infection derived immunity. It also makes variant targeting boosters even more futile, as it appears that the most recent dominant variant(s) such as BA4/BA5 often specifically evolved to evade antibodies elicited against previous variants including the one presumably targeted by whatever updated vaccines. Not really hopeful about updated mRNA vaccines this fall given this.
It is low-key impressive that Bebtelovimab still works against every variant, but this is probably in large part due to limited availability. Not enough people have been treated with it so far to exert any real selection pressure, and IIRC there are known mutations that would decrease it's effectiveness that would like become selected if everyone could get it.
redmanjp wrote:boosters approved for 12-18 yr olds. date for receipt of 5-11 yr old vax within the next week
https://newsday.co.tt/2022/05/11/deyalsingh-pfizer-boosters-approved-for-12-18-age-group/
sMASH wrote:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415024/
ivermectin has been studied for its link to cancer
De Dragon wrote:sMASH wrote:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415024/
ivermectin has been studied for its link to cancer
So whichever hole yuh put it een, it good to go?
paid_influencer wrote:some news and updates:
Pediatric vaccines to get here hopefully next week!!!!!!!!!! Kids who are vulnerable really need these. Thank God the pediatric vaccines are finally arriving on the island soon.
https://tt.loopnews.com/content/paediat ... n-route-tt
redmanjp wrote:paid_influencer wrote:some news and updates:
Pediatric vaccines to get here hopefully next week!!!!!!!!!! Kids who are vulnerable really need these. Thank God the pediatric vaccines are finally arriving on the island soon.
https://tt.loopnews.com/content/paediat ... n-route-tt
it has arrived!
https://www.guardian.co.tt/news/pediatric-pfizer-covid19-vaccines-have-arrived-in-tt-6.2.1496516.00f8f7732d
timelapse wrote:I'm sure certain PNM officials want to personally inject some kids...
It's not ah ledge, it's a fax!De Dragon wrote:timelapse wrote:I'm sure certain PNM officials want to personally inject some kids...
Yuh flirting with a zr ban eh!
Who the cap fit, let them wear it -De Dragon wrote:timelapse wrote:I'm sure certain PNM officials want to personally inject some kids...
Yuh flirting with a zr ban eh!
Return to “Ole talk and more Ole talk”
Users browsing this forum: No registered users and 117 guests